– Discuss and critically analyse how newly born neurons

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Discuss and critically analyse how newly born neurons contribute to adult brain function in humans and why their continuous renewa

ESSAY PLAN

INTRODUCTION (~300 words)

• Adult neurogenesis: definition, historical approaches

• Introduction of the hippocampus

• Hippocampal neurogenesis as present focus of the essay

• Brief introduction to Spalding et al study as starting point (Spalding et al., 2013)

BODY (~1000 words)

• Brief discussion and analysis of Spalding study

o Methodology (nuclear bomb)

o Key findings

• The functions of adult hippocampal neurogenesis

• Discuss some environmental factors that can influence adult hippocampal neurogenesis

• Other advances that has been used to investigate neurogenesis among adult humans [, zebrafish, rodents] since 2013

o in relation to neurodegenerative and neurocognitive disorders (i.e. epilepsy (Danzer, 2019)

o in area of deferring aging (memory loss, decline in cognitive functions etc)

o in relation to depression and addictions

CONCLUSION (~200 words)

• Advances in the neuroscience successfully challenge he past conclusions that brain cells, including neurons, develop mainly during childhood

• Hippocampal neurogenesis provides a good base for further understanding, investigating, diagnosing, and treating various neurological conditions/disorders/diseases affecting humankind

• Future is in further research and empirical studies to better understand the nature of neurogenesis and to expand its potential

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