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Identification Screening Eligibility Modified from Moher et al. (2009) & The PRISMA Group Appraisal Flow Chart Diagram to Show Process for Narrowing Down to “Keeper” Studies Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6(7): e1000097. doi:10.1371/journal.pmed1000097 Additional records identified through other sources (n = ) Records after duplicates removed (n = ) Article abstracts screened (n = ) Abstracts excluded (n = ) Full-text articles assessed for eligibility (n = ) Full-text articles excluded, with reasons (n = ) Articles appraised for quality (n = ) Excluded due to quality concerns (n = ) Articles summarized in evaluation (summary) tables (n = ) Included The 2009 Moher et al. paper is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Records identified through database searching (n = ) Articles included in synthesis tables (n = )

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